Alzheimer's disease is a progressive, incurable and ultimately fatal form of dementia. The symptoms of Alzheimer's disease occur because of the loss of neurons. One of the key features of Alzheimer's is the presence of aggregated proteins, also called amyloid fibrils. These fibrils are made up of the A-beta protein, which can form the starting core for these clumps on the cell membrance which may lead to Alzheimer's.
http://www.livestrong.com/article/23368-alzheimers-cell-disease/
1.) One theory about how Alzheimer's develops is the ability of these amyloid fibrils to disrupt the internal workings of neurons. How do these fibrils destroy neurons, and why do the cells not rid themselves of these damaged proteins?
2.) Explain the process of Apoptosis and does this process help or eventually hurt neurons?
http://www.sciencedaily.com/releases/2010/06/100625124544.htm
1.) High levels of aneuploidy may result in developmental abnormalities and disease. Explain why this occurs, and what the outcome for the patient may be.
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1.The build up of A-Beta protiens is toxic to the cell. All cells, including neurons, have the ability to process damaged or misfolded proteins to prevent them from damaging the cell, so the protiens are not discarded.
ReplyDelete2.Apoptosis is a mechanism by which severely damaged cells self-destruct, which limits the damage done to surrounding cells. This is good to have on a minor scale, but when too many cells self-destruct it could cause serious and prolonged damage.
3.High levels of aneuplody cause greater than the normal number of chromosomes, in Alzheimer's disease pathogenesis. This causes more A-beta protiens to make cells self-destruct.
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ReplyDelete1. a protien called a beta protien wihich forms in clumps of protien. cells have the a bility to process damaged or misfolded protiens to prevent them from damaging
ReplyDelete2. Apoptosis is a mechanism by which severely damaged cells self-destruct, which limits the damage done to surrounding cells. this is ok if too many cells dont do it but if they do it could cause serious damage
3. higher levels of aneupliody cause greater amounts of chromosomes. this makes a beta cause cells to self destruct
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ReplyDeletehttp://www.youtube.com/watch?v=9Wv9jrk-gXc
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